UFC president Dana White has confirmed that Heavyweight champion Junior dos Santos will defend his title at UFC 146 according to a report from the Associated Press. Dos Santos, who took the belt from Cain Velasquez last November at UFC on Fox, had been scheduled to face Alistair Overeem.
That fight was apparently scotched when Overeem failed a 'surprise' drug test after a press conference in Las Vegas. No official action has been taken, but as Overeem wasn't licensed in Nevada it seems exceedingly unlikely that the Nevada State Athletic Commission will extend that privilege to him now that he's tested over the limit for Testosterone.
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Fans are clamoring for the UFC to bring in former Pride champion Fedor Emelianenko or to give Mark Hunt a chance to play 'Rocky' but it seems most likely that Frank Mir will get the title shot. Mir is riding a three-fight win streak, including a dramatic come-from-behind win over Antonio Rodrigo Nogueira at UFC 140.